Scientific Publication
Scientific Publications
Glioblastoma
- 2022 | Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance
- 2022 | Biodegradable Controlled-release Polymer Containing Butylidenephthalide to Treat a Recurrent Cervical Spine Glioblastoma with Promising Result: a Compassionate Trial Report
- 2022 | Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM
- 2020 | Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain
- 2018 | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment
- 2017 | n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
- 2015 | Biodegradable Interstitial Release Polymer Loading a Novel Small Molecule Targeting Axl Receptor Tyrosine Kinase and Reducing Brain Tumour Migration and Invasion
- 2014 | Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability
- 2013 | The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors
- 2013 | (Z)-Butylidenephthalide restores Temozolomide sensitivity to Temozolomide-resistant malignant glioma cells by downregulating expression of the DNA repair enzyme MGMT.
- 2011 | Overexpression of the Orphan Receptor Nur77 and Its Translocation Induced by PCH4 May Inhibit Malignant Glioma Cell Growth and Induce Cell Apoptosis
- 2011 | Local Interstitial Delivery of z-Butylidenephthalide by Polymer Wafers against Malignant Human Gliomas
- 2011 | Butylidenephthalide suppresses human telomerase reverse transcriptase (TERT) in human glioblastomas
- 2010 | Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth
- 2008 | Orphan Nuclear Receptor, Nurr-77 was a Possible Target Gene of Butylidenephthalide Chemotherapy on Glioblastoma Multiform Brain Tumor
- 2006 | The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo
- 2005 | The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo
- 2004 | Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis
Pancratic Cancer
Neurodegenerative Disease
- 2024 | n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs
- 2023 | Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function
- 2022 | Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs
- 2021 | n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
- 2020 | Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease
- 2018 | Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
- 2017 | Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
- 2016 | Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice
- 2015 | N-butylidenephthalide Attenuates Alzheimer's Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons
Fibrotic disease
- 2018 | Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
- 2018 | Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis
- 2016 | The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
Others
- 2012 | Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide
- 2011 | Inhibitory Effect of n-Butylidenephthalide on Neointimal Hyperplasia in Balloon Injured Rat Carotid Artery
- 2004 | Telomerase and c-myc expression in hepatocellular carcinomas
