{"id":6277,"date":"2023-09-12T10:07:51","date_gmt":"2023-09-12T02:07:51","guid":{"rendered":"https:\/\/www.efbiotech.com\/wordpress\/?page_id=6277"},"modified":"2024-07-18T09:30:28","modified_gmt":"2024-07-18T01:30:28","slug":"protecting-brain-health-the-blood-brain-barrier","status":"publish","type":"page","link":"https:\/\/www.efbiotech.com\/wordpress\/?page_id=6277","title":{"rendered":"Protecting Brain Health &#8211; The Blood-Brain Barrier"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6277\" class=\"elementor elementor-6277\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1379a70c elementor-section-full_width elementor-section-stretched elementor-hidden-mobile elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"1379a70c\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-69040160\" data-id=\"69040160\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65175abd elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"65175abd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.5 - 14-03-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1366\" height=\"456\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier.png\" class=\"attachment-full size-full wp-image-7113\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier.png 1366w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-300x100.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-1024x342.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-768x256.png 768w\" sizes=\"(max-width: 1366px) 100vw, 1366px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37440f5c elementor-widget elementor-widget-spacer\" data-id=\"37440f5c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.5 - 14-03-2023 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1cc66a95 elementor-section-full_width elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"1cc66a95\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e105dc8\" data-id=\"5e105dc8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23cab0b3 elementor-widget-mobile__width-inherit elementor-widget elementor-widget-image\" data-id=\"23cab0b3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone.png\" class=\"attachment-full size-full wp-image-7114\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone.png 1080w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone-1024x1024.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone-150x150.png 150w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/Brain-Barrier-phone-768x768.png 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c25c64e elementor-widget elementor-widget-spacer\" data-id=\"3c25c64e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-121ffcd elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"121ffcd\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-36b97dc0\" data-id=\"36b97dc0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5012c473 elementor-widget elementor-widget-heading\" data-id=\"5012c473\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.5 - 14-03-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-medium\">Protecting Brain Health - The Blood-Brain Barrier (BBB)<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2866487c elementor-widget elementor-widget-text-editor\" data-id=\"2866487c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.5 - 14-03-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p style=\"text-align: center;\">The role of the blood-brain barrier is akin to that of a robust defense wall, ensuring the brain remains shielded from external threats while maintaining internal stability and balance.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39ed829b elementor-widget elementor-widget-text-editor\" data-id=\"39ed829b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">The blood-brain barrier (BBB), often an overlooked biological barrier, plays a profoundly significant role as the guardian of our brain. It functions as an impenetrable checkpoint, safeguarding our brain from the invasion of harmful substances. While it serves as a crucial barrier for the health of individuals, it can pose challenges for patients requiring drug therapies to treat brain-related conditions, as this barrier makes it difficult for drugs to reach the affected areas, thereby reducing therapeutic efficacy. Let&#8217;s delve into the enigmatic aspects of this barrier and the challenges it presents in drug development.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b7696ad elementor-widget elementor-widget-spacer\" data-id=\"5b7696ad\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-526daddf elementor-widget elementor-widget-heading\" data-id=\"526daddf\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">What is the Blood-Brain Barrier?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137e177b elementor-widget elementor-widget-text-editor\" data-id=\"137e177b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">The blood-brain barrier (BBB), also known as the blood-cerebrospinal fluid barrier, resides between the cerebral vascular system and the central nervous system. It comprises highly specialized endothelial cells that line brain capillaries and transmit signals between the vascular system and the brain. The structure and function of the BBB depend on intricate interactions among different cell types, such as endothelial cells, pericytes, and astrocytes, as well as the extracellular matrix in the microvasculature of the brain. These cells are densely packed, preventing the majority of substances from entering brain tissue. Its primary role is to protect the brain from harmful substances like toxins, bacteria, and viruses present in the bloodstream while regulating the transport of essential molecules and maintaining a stable environment.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-687897f8 elementor-widget elementor-widget-heading\" data-id=\"687897f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">Structure of the Blood-Brain Barrier<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1600695e elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"1600695e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2b9a55ee\" data-id=\"2b9a55ee\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23854e2c elementor-widget elementor-widget-image\" data-id=\"23854e2c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB.png\" class=\"attachment-full size-full wp-image-6280\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB.png 1080w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB-1024x1024.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB-150x150.png 150w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/BBB-768x768.png 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-5a94695\" data-id=\"5a94695\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3277f14f elementor-widget elementor-widget-text-editor\" data-id=\"3277f14f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">The protective barrier of the brain, collectively referred to as the &#8220;blood-brain barrier,&#8221; encompasses four primary interfaces between the central nervous system (CNS) and the periphery. While the barrier allows for the passage of oxygen, carbon dioxide, glucose, water, hormones, and certain lipid-soluble or nano-sized molecules, most drugs, proteins, and bacteria are typically too large to pass through.<\/span><\/p><ol><li><span style=\"color: #0d344a;\"><strong>Blood-Brain Barrier:<\/strong> Formed by tight junctions between endothelial cells of brain blood vessels. Pericytes are capable of inducing certain barrier properties in endothelial cells, while astrocytes help maintain the integrity of the blood-brain barrier postnatally.<\/span><\/li><li><span style=\"color: #0d344a;\"><strong>Blood-Cerebrospinal Fluid Barrier:<\/strong> Formed by tight junctions between epithelial cells of the choroid plexus. Note that choroid plexus blood vessels have fenestrations (small openings). Immune cells are present on the surface of choroid plexus.<\/span><\/li><li><span style=\"color: #0d344a;\"><strong>Brain-Cerebrospinal Fluid Barrier:<\/strong> Located between endothelial cells of dural blood vessels at the interface with the dura mater.<\/span><\/li><li><span style=\"color: #0d344a;\"><strong>Cerebrospinal Fluid-Brain Barrier:<\/strong> Present only during early developmental stages and formed by belt-like connections between neuroepithelial cells lining the brain ventricles. In adults, this barrier no longer exists.<\/span><\/li><\/ol><p><span style=\"color: #0d344a;\">The blood-brain barrier and cerebrospinal fluid-brain barrier extend into the spinal cord. <strong>Cerebrospinal fluid, filling the ventricular system of the brain, is represented in blue, while central nervous system brain tissue is depicted in brown.<\/strong><\/span><\/p><p><span style=\"color: #0d344a;\">(Source: Stolp HB, Liddelow SA, S\u00e1-Pereira I, Dziegielewska KM and Saunders NR (2013) Immune responses at brain barriers and implications for brain development and neurological function in later life. Front. Integr. Neurosci. 7:61. doi: 10.3389\/fnint.2013.00061 <\/span><a class=\"external free\" href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnint.2013.00061\/full\" rel=\"nofollow\">http:\/\/journal.frontiersin.org\/article\/10.3389\/fnint.2013.00061\/full<\/a>)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-5afbd084 elementor-widget elementor-widget-spacer\" data-id=\"5afbd084\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1cc4fb0b elementor-widget elementor-widget-heading\" data-id=\"1cc4fb0b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">The Importance of the Blood-Brain Barrier<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-18b52701 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"18b52701\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4a44576d\" data-id=\"4a44576d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3686ad0d elementor-widget elementor-widget-text-editor\" data-id=\"3686ad0d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">The function of the blood-brain barrier (BBB) is analogous to that of a robust defense wall, ensuring the brain remains impervious to external threats while maintaining the stability and equilibrium of its internal environment. Its normal functioning is of paramount importance to our neurological health and overall well-being:<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4bd28e8 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"4bd28e8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-061d6a9\" data-id=\"061d6a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f172e97 elementor-widget elementor-widget-image\" data-id=\"f172e97\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection.png\" class=\"attachment-full size-full wp-image-7123\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection.png 1080w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection-1024x1024.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection-150x150.png 150w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/brain-protection-768x768.png 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-d7b6ac4\" data-id=\"d7b6ac4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e37be78 elementor-widget elementor-widget-text-editor\" data-id=\"e37be78\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\n<p><span style=\"color: #0d344a;\"><strong>Shielding the Brain from Harmful Intrusions:<\/strong> One of the primary roles of the BBB is to filter potential harmful substances, such as bacteria, toxins, and viruses, from the bloodstream, preventing their entry into brain tissue. This contributes to the preservation of brain health and function.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: #0d344a;\"><strong>Regulating the Transport of Essential Molecules:<\/strong> The BBB is also responsible for transporting vital molecules into the brain, including glucose, oxygen, and nutrients. This ensures that the brain receives the necessary energy and nutrients to sustain its normal operations.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: #0d344a;\"><strong>Maintaining a Stable Environment:<\/strong> The BBB helps maintain a stable ecosystem within the brain, including factors like pH levels, concentrations of sodium, potassium, and calcium ions, among others. These factors are critical for the proper functioning of neurons, as neurons are highly sensitive to fluctuations in this environment.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: #0d344a;\"><strong>Restricting the Entry of Immune Cells:<\/strong> Typically, the BBB limits the entry of immune cells into the brain. This helps prevent excessive inflammatory responses and protects brain tissue from immune system-related damage. This is also one of the reasons why the brain is considered a specialized immunoregulatory region.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: #0d344a;\"><strong>Sustaining the Stability of the Nervous System:<\/strong> The BBB not only safeguards the brain but also ensures the stability of other components of the central nervous system, including the spinal cord and peripheral nervous tissues. This contributes to maintaining the proper functioning of the entire nervous system.<\/span><\/p><\/li><\/ol><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-27cbec6 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"27cbec6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4595b15\" data-id=\"4595b15\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bca0a9c elementor-widget elementor-widget-text-editor\" data-id=\"bca0a9c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">In essence, the BBB acts as a critical gatekeeper, allowing essential substances to enter the brain while barring potentially harmful agents. Its proper functioning is indispensable for the preservation of neurological health and the overall well-being of an individual.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-4123471b elementor-widget elementor-widget-spacer\" data-id=\"4123471b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-797df46c elementor-widget elementor-widget-heading\" data-id=\"797df46c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">Current Breakthrough Approaches to Overcoming the Blood-Brain Barrier for Treatment<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c2d0551 elementor-widget elementor-widget-text-editor\" data-id=\"5c2d0551\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0d344a;\">When diseases affect the central nervous system, such as the brain and spinal cord, the majority of drugs used for treatment are often hindered by the blood-brain barrier (BBB) from reaching the affected areas. Consequently, there are significant challenges in treating conditions like neurodegenerative diseases, including Alzheimer&#8217;s disease, Parkinson&#8217;s disease, <a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=5863\">amyotrophic lateral sclerosis<\/a> (ALS), or <a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=5824\">brain tumors<\/a>, among others.<\/span><\/p><p><span style=\"color: #0d344a;\">Due to the limited number of drugs that can currently access the brain through methods such as oral administration or injections, this has remained a pivotal challenge in the development of new therapies.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3f70608 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"3f70608\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6edcc0c\" data-id=\"6edcc0c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7495624 elementor-widget elementor-widget-image\" data-id=\"7495624\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1200\" height=\"1200\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6.png\" class=\"attachment-full size-full wp-image-7231\" alt=\"CEREBRACA\u00ae WAFER\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6.png 1200w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6-1024x1024.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6-150x150.png 150w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2024\/03\/cerebraca-wafer-product-6-768x768.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-0e10662\" data-id=\"0e10662\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5ebcde4 elementor-widget elementor-widget-text-editor\" data-id=\"5ebcde4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h6><strong><span class=\"lead solid-color\">CEREBRACA\u00ae<\/span> WAFER &lt;Phase IIa&gt;&nbsp; <a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=1778\">&gt;&gt;more<\/a><\/strong><\/h6>\n<ul>\n<li><span style=\"color: #0d344a;\"><b>Cerebraca<\/b>\u00ae<b>&nbsp;Wafer <\/b>developed by Everfront Biotech Inc.<b>&nbsp;<\/b>is a therapeutic drug wafer that can be used to treat highly malignant glioblastoma (malignant brain cancer). It can be directly implanted into the brain and slowly releases drugs at a high concentration, high penetration, and long duration for about 1 month, exerting a multi-target effect that helps to treat cancer and make cancer cells more susceptible to chemotherapy or immune cell killing.<\/span><\/li>\n<li><span style=\"color: #0d344a;\">Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that can&nbsp;<strong>grow up to 16 times<\/strong>&nbsp;its original size within a month. It has a high rate of recurrence after surgical resection, and there are currently&nbsp;<strong>no effective treatment options available<\/strong>.<\/span><\/li>\n<li><span style=\"color: #0d344a;\"><b>EF-API-001,&nbsp;<\/b>the small molecule active pharmarceutical ingredient&nbsp; in&nbsp;<b>Cerebraca<\/b>\u00ae<b>&nbsp;Wafer<\/b>, has the following characteristics:<\/span>\n<ul>\n<li><span style=\"color: #0d344a;\"><strong>Targeting&nbsp;Axl-1 receptor tyrosine kinase:<\/strong>&nbsp;effectively inhibits the growth and metastasis of brain tumor stem cells.<\/span><\/li>\n<li><span style=\"color: #0d344a;\"><strong>Inhibiting the PD-L1 immune checkpoint:&nbsp;<\/strong>reduces the immune suppressive nature of the tumor microenvironment, thus preserving the activity of immune cells to kill tumor cells.&nbsp;<\/span><\/li>\n<li><span style=\"color: #0d344a;\"><strong>Inhibition of MGMT DNA repair enzyme:<\/strong>&nbsp;overcomes resistance to Temozolomide (chemotherapy drug) and enables cancer cells to be killed again by chemotherapy.<\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #0d344a;\"><b>Cerebraca<\/b>\u00ae<b>&nbsp;Wafer<\/b>, its small molecule active ingredient and biodegradable polymer are all manufactured by internationally renowned PIC\/S GMP pharmaceutical companies in Taiwan to ensure high quality and reliable aseptic manufacturing processes.<\/span><\/li>\n<\/ul>\n<div>&nbsp;<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-25807310 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"25807310\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6ff65069\" data-id=\"6ff65069\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1775a6bd elementor-widget elementor-widget-image\" data-id=\"1775a6bd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c.png\" class=\"attachment-full size-full wp-image-6261\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c.png 1080w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c-1024x1024.png 1024w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c-150x150.png 150w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/09\/\u9577\u5e9a\u81e8\u5e8a\u8a66\u9a57\u8840\u8166\u5c4f\u969c-768x768.png 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-2b074bba\" data-id=\"2b074bba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44ec6504 elementor-widget elementor-widget-text-editor\" data-id=\"44ec6504\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h6><span style=\"color: #0d344a;\"><strong>[Focused Ultrasound Focus]: Opening the Blood-Brain Barrier to Facilitate Brain Drug Delivery &lt;Phase II&gt;<\/strong><\/span><\/h6><ul><li><p><span style=\"color: #0d344a;\">Focused ultrasound is a non-invasive energy source that can penetrate the skull. When combined with microbubbles, it can temporarily open the blood-brain barrier in specific brain regions, allowing for the delivery of chemotherapeutic agents to eliminate tumors. It can also be used for localized neural modulation to treat degenerative neurological diseases.<\/span><\/p><\/li><li><p><span style=\"color: #0d344a;\">The NaviFUS navigational focused ultrasound system under the Haoyu Biomedical, which was licensed from Chang Gung University, has completed Phase II clinical trials. According to clinical data, the primary efficacy endpoint is the 6-month progression-free survival (PFS-6). It demonstrates that the NaviFUS System, when used in conjunction with Avastin, enhances the efficiency of drug penetration through the blood-brain barrier, resulting in a superior 6-month progression-free survival rate compared to historical standard treatment data.<\/span><\/p><\/li><\/ul><p><span style=\"color: #0d344a;\">(Source: <\/span><a href=\"https:\/\/news.ltn.com.tw\/news\/life\/paper\/1436403\">https:\/\/news.ltn.com.tw\/news\/life\/paper\/1436403<\/a> and <a href=\"https:\/\/news.cnyes.com\/news\/id\/5300896\">https:\/\/news.cnyes.com\/news\/id\/5300896<\/a><span style=\"color: #0d344a;\">)<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-622be2c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"622be2c0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-461e4b1d\" data-id=\"461e4b1d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-60f592e9 elementor-widget elementor-widget-image\" data-id=\"60f592e9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/04\/\u91dd\u5291.png\" class=\"attachment-full size-full wp-image-2803\" alt=\"\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/04\/\u91dd\u5291.png 400w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/04\/\u91dd\u5291-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/04\/\u91dd\u5291-150x150.png 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-26084666\" data-id=\"26084666\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-76bcfaad elementor-widget elementor-widget-text-editor\" data-id=\"76bcfaad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h6><span style=\"color: #0d344a;\"><strong>[ETV Enzyme Transport Vehicle] DNL310 &lt;Phase I\/II&gt;<\/strong><\/span><\/h6>\n<ul>\n<li>\n<p><span style=\"color: #0d344a;\">DNL310, developed by Denali Therapeutics Inc., is a therapeutic drug designed to treat MPS II (Hunter syndrome). It is an investigational fusion protein comprising IDS (iduronate 2-sulfatase) and Denali&#8217;s Enzyme Transport Vehicle (ETV), which is an engineered soluble enzyme fused with the Fc region. This fusion protein has been engineered to bind to the transferrin receptor, facilitating transport across the blood-brain barrier through receptor-mediated transcytosis, thus enabling passage into the brain.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: #0d344a;\">Mid-stage research data for DNL310 in MPS II has demonstrated positive effects on core biomarkers, including the normalization of heparan sulfate and a reduction in NfL (neurofilament light). These findings continue to support the development of DNL310 for MPS II. Recruitment for this study is ongoing.<\/span><\/p>\n<\/li>\n<\/ul>\n<p><span style=\"color: #0d344a;\">(Source: <a href=\"https:\/\/www.biospace.com\/article\/releases\/denali-therapeutics-announces-new-interim-data-from-phase-1-2-study-of-dnl310-etv-ids-in-mps-ii-hunter-syndrome-at-ssiem-2023\/\">https:\/\/www.biospace.com\/article\/releases\/denali-therapeutics-announces-new-interim-data-from-phase-1-2-study-of-dnl310-etv-ids-in-mps-ii-hunter-syndrome-at-ssiem-2023\/<\/a>)<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-30781ad9 elementor-widget elementor-widget-spacer\" data-id=\"30781ad9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69f33b3b elementor-widget elementor-widget-heading\" data-id=\"69f33b3b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">Reference<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-baa9ecc elementor-widget elementor-widget-text-editor\" data-id=\"baa9ecc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol><li><a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnint.2013.00061\/full\">http:\/\/journal.frontiersin.org\/article\/10.3389\/fnint.2013.00061\/full<\/a><\/li><li><a href=\"https:\/\/news.ltn.com.tw\/news\/life\/paper\/1436403\">https:\/\/news.ltn.com.tw\/news\/life\/paper\/1436403<\/a><\/li><li><a href=\"https:\/\/www.biospace.com\/article\/releases\/denali-therapeutics-announces-new-interim-data-from-phase-1-2-study-of-dnl310-etv-ids-in-mps-ii-hunter-syndrome-at-ssiem-2023\/\">https:\/\/www.biospace.com\/article\/releases\/denali-therapeutics-announces-new-interim-data-from-phase-1-2-study-of-dnl310-etv-ids-in-mps-ii-hunter-syndrome-at-ssiem-2023\/<\/a><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a9b6028 elementor-widget elementor-widget-spacer\" data-id=\"5a9b6028\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eedb3f elementor-widget elementor-widget-heading\" data-id=\"7eedb3f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<span class=\"elementor-heading-title elementor-size-default\">This article is provided for informational purposes only regarding industry information. The development of new drugs involves lengthy timelines, high financial investments, and is not guaranteed to be successful. These factors may expose investors to risks, and therefore, investors should exercise caution and prudence when making investment decisions.<\/span>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d4dcced elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"4d4dcced\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2f484187\" data-id=\"2f484187\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53f259a1 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"53f259a1\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.5 - 14-03-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#2c2c2c;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8fa3e8 elementor-widget elementor-widget-heading\" data-id=\"a8fa3e8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Development Pipeline<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8c2b18b elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"8c2b18b\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-767f430\" data-id=\"767f430\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-303e039 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"303e039\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3627c8e\" data-id=\"3627c8e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3931227 elementor-widget elementor-widget-image\" data-id=\"3931227\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pipeline-1.png\" class=\"attachment-large size-large wp-image-1709\" alt=\"Pepline - EF-001\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pipeline-1.png 400w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pipeline-1-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pipeline-1-150x150.png 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e574ee elementor-align-center e-transform e-transform elementor-widget elementor-widget-button\" data-id=\"7e574ee\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_scale_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.03,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=1778\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">EF-001<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c465230\" data-id=\"c465230\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9b27a84 elementor-widget elementor-widget-image\" data-id=\"9b27a84\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-2.png\" class=\"attachment-large size-large wp-image-1710\" alt=\"Pepline - EF-009\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-2.png 400w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-2-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-2-150x150.png 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9013959 elementor-align-center e-transform e-transform elementor-widget elementor-widget-button\" data-id=\"9013959\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_scale_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.03,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=1870\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">EF-009<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d87bfba\" data-id=\"d87bfba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e34f495 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"e34f495\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-19e6d24\" data-id=\"19e6d24\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef92122 elementor-widget elementor-widget-image\" data-id=\"ef92122\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-3.png\" class=\"attachment-large size-large wp-image-1711\" alt=\"Pepline - HK-001\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-3.png 400w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-3-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/pepline-3-150x150.png 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10d1abc elementor-align-center e-transform e-transform elementor-widget elementor-widget-button\" data-id=\"10d1abc\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_scale_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.03,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=3417\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">HK-001<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5ba9874\" data-id=\"5ba9874\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2d8e3f elementor-widget elementor-widget-image\" data-id=\"b2d8e3f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/Pepline-4-1.png\" class=\"attachment-large size-large wp-image-1713\" alt=\"Pepline - EF-031\" srcset=\"https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/Pepline-4-1.png 400w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/Pepline-4-1-300x300.png 300w, https:\/\/www.efbiotech.com\/wordpress\/wp-content\/uploads\/2023\/03\/Pepline-4-1-150x150.png 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff786c2 elementor-align-center e-transform e-transform elementor-widget elementor-widget-button\" data-id=\"ff786c2\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_scale_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.03,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.1,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleX_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scaleY_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/www.efbiotech.com\/wordpress\/?page_id=5401\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">EF-031<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Protecting Brain Hea<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6277"}],"collection":[{"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6277"}],"version-history":[{"count":10,"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6277\/revisions"}],"predecessor-version":[{"id":9466,"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6277\/revisions\/9466"}],"wp:attachment":[{"href":"https:\/\/www.efbiotech.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}